Weekly Roundup for NOVEMBER 29, 2019: Recent Publications in Women’s Mental Health

By | December 6, 2019

Prenatal Developmental Origins of Future Psychopathology: Mechanisms and Pathways.

Monk C, Lugo-Candelas C, Trumpff C.  Annu Rev Clin Psychol. 2019 May 7;15:317-344.

This article reviews several biological systems hypothesized to be mechanisms by which maternal distress affects fetal and child brain and behavior development, as well as the clinical implications of studies of the developmental origins of health and disease that focus on maternal distress. 


Maternal inflammation during pregnancy and offspring psychiatric symptoms in childhood: Timing and sex matter.

Mac Giollabhui N, Breen EC, Murphy SK, Maxwell SD, Cohn BA, Krigbaum NY, Cirillo PM, Perez C, Alloy LB, Drabick DAG, Ellman LM.  J Psychiatr Res. 2019 Apr;111:96-103. 

Elevated maternal inflammation during pregnancy is associated with the emergence of separate psychological phenotypes in the offspring.  Elevated IL-8 in the first trimester was associated with significantly higher levels of externalizing symptoms in offspring. Higher IL-1 in the second trimester was associated with higher offspring internalizing symptoms. Further, second trimester IL-1 was associated with increased internalizing symptoms in females only.


Maternal loneliness: concurrent and longitudinal associations with depressive symptoms and child adjustment.

Luoma I, Korhonen M, Puura K, Salmelin RK.Psychol Health Med. 2019 Jul;24(6):667-679. 

Some 34-38% of the mothers reported loneliness at the different study points. Maternal loneliness showed associations with dissatisfaction with life and the pair relationship, and with the presence of depressive symptoms. The mother’s prenatal loneliness predicted the child’s internalizing problems in adolescence.


Maternal prenatal depressive symptoms and risk for early-life psychopathology in offspring: genetic analyses in the Norwegian Mother and Child Birth Cohort Study.

Hannigan LJ, Eilertsen EM, Gjerde LC, Reichborn-Kjennerud T, Eley TC, Rijsdijk FV, Ystrom E, McAdams TA.  Lancet Psychiatry. 2018 Oct;5(10):808-815.

Prenatal depressive symptoms were found to be associated with early-life psychopathology primarily via intergenerationally shared genetic factors, which explained 41% (95% CI 36-46) of variance in children’s internalising problems and 37% (30-44) of variance in children’s externalising problems.


Maternal depression impacts child psychopathology across the first decade of life: Oxytocin and synchrony as markers of resilience.

Priel A, Djalovski A, Zagoory-Sharon O, Feldman R.  J Child Psychol Psychiatry. 2019 Jan;60(1):30-42. 

Maternal depression continues to play a role in children’s development beyond infancy. The mediating effects of oxytocin and synchronous, mutually regulated interactions underscore the role of plasticity in resilience.


Pre- and post-natal maternal anxiety and early childhood weight gain.

Nawa N, Black MM, Araya R, Richiardi L, Surkan PJ.  J Affect Disord. 2019 Oct 1;257:136-142.

Maternal anxiety around childbirth was associated with modest increases in child BMI gain during the child’s second year of life.

MGH Center for Women's Mental Health