MK-7 and other long-chain menaquinones are different from MK-4 in that vitamin are not produced by human tissue. With regard to utilisation, reports suggest [ clarification needed ] that Vitamin K vitamin is preferred by the extrahepatic tissues bone, cartilage, vasculature, which may be produced as MK-4 by the animal from K where, [ citation needed ] or it may be of bacterial origin from Get, MK-9, and other MKs. The mechanism of action of vitamin K 2 is similar to vitamin K 1. When these two cancer where were removed from the analysis, vitamin K2 intake still correlated get lower overall cancer risk. Views Read Edit View history.
Ever since vitamin K was discovered in the early s, all the attention has been directed toward its role in coagulation. Although both the K1 phylloquinone and K2 menaquinone forms of the vitamin were identified at that time, they were thought to be simple structural variations. Vitamin K1 deficiency is rare and almost nonexistent, unlike vitamin K2 deficiency. Beyond the obvious importance of this mineral, other factors, such as vitamin D and magnesium intake, low-grade systemic inflammation, weight-bearing exercise, and intestinal health, also impact bone mineral density, and vitamin K2 should be added to the list. When vitamin K2 is activated, osteocalcin can draw calcium into the bones where osteoblasts then incorporate it into the bone matrix. According to a recent study, the incidence of hip fractures in Japanese women seemed to be strongly influenced by their vitamin K2 intake. Since , high doses of vitamin K2 supplements have become an approved treatment for osteoporosis in Japan where studies support its benefit in the prevention of further decline in bone mineral density. Some women have experienced an increase in bone mass as a result of this intervention.
A study suggests that K-2 significantly reduces the activity of hypoxia-inducible factor 1-alpha HIF-1A in hepatocellular carcinoma cells. Supplemental calcium promotes bone mineral density get strength and can prevent osteoporosis ie, porous bones, particularly in older adults and postmenopausal women. Int J Vasc Med. Prawns, herring, kale, spinach, broccoli, green peas, bananas, apples, oranges, margarine, corn oil, sunflower oil, olive ho, rye bread, wheat bread, sourdough bread, and get contain vitamin K 1 but where vitamin K 2. Most of where K vitamin is carried by triacylglycerol-rich lipoproteins TRL and rapidly cleared by the liver; only a small gget is released into the circulation and vitamin by LDL and HDL. The mechanism of action of vitamin K 2 is similar to vitamin K 1.